教育经历:

1995.09-1999.06河北科技师范学院，食品工程系， 学士学位

1999.09-2002.09 沈阳农业大学，食品学院， 硕士学位，

2002.09-2005.10 天津科技大学，生物工程学院， 博士学位

工作经历:

2002.09-2006.12：助教、讲师，天津理工大学生物与化学工程学院

2007.04-2008.07：研究员，美国亚利桑那州Genosensor Company公司

2008.08-2010.03：助理研究员，美国亚利桑那州立大学生物设计学院

2011.06-2012.12：高级助理研究员，美国亚利桑那州立大学生物设计学院

2013.01-2015.09：讲师，四川农业大学动物医学院

2017.09-现在：讲师，西南大学mobile288-365

研究项目

1.       国家自然基金青年项目，31200697，2013.01-2016.12，主持（结题）。

2.       国家自然基金面上项目，31270981，2013.01-2016.12，主要参与者（结题）。

3.       国家自然基金面上项目，31472179，2015.01-2018.12，主持（在研）。

期刊文章：

自工作以来，先后发表研究论文20余篇，主要成果如下：

1.       Yue Han, Qing Liu, Qingke Kong, Attenuated Salmonella Typhimurium delivering avian pathogenic Escherichia coli O1 O-antigen polysaccharide induces immune responses and provides protection against challenge of infection, Pathogens and Diseases, online.

2.       Yue Han*, Qing Liu*（共同第一作者）, Kang Liang, Qingke Kong. Construction of a balanced lethal shuttle vector for facilitating cloning large gene fragments and its application for delivering a biologically conjugated O-antigen polysaccharide vaccine by attenuated Salmonella Typhimurium, submitted to Microbial cell factories, under revision.

3.       Qiong Liu*, Qing Liu*（共同第一作者）, Kenneth Roland, Qingke Kong. Outer membrane vesicles derived from Salmonella Typhimurium mutants with truncated LPS induce cross-protective immune responses against infection of Salmonella enterica serovars in the mouse model, International journal of Medical Microbiology, published online.

4.       Pei Li*, Qing Liu*（共同第一作者）, Chun Huang, Kenneth Roland, Qingke Kong. Reversible synthesis of colanic acid and O-antigen polysaccharides in Salmonella Typhimurium enhances induction of cross-immune responses and protection against heterologous Salmonella challenge, Vaccine, 2017 35 (21): 2862-2869.

5.       Qiong Liu*, Qing Liu*（共同第一作者）, Kenneth L. Roland,  Qingke Kong. Outer membrane vesicles from flagellin-deficient Salmonella enterica serovar Typhimurium induce cross-reactive immunity and provide cross-protection against heterologous Salmonella challenge, International Journal of Medical Microbiology, 2016.

6.       Chun Huang*, Qing Liu*（共同第一作者）, Pei Li, Qingke Kong. Regulated delayed synthesis of lipopolysaccharide and enterobacterial common antigen of Salmonella Typhimurium enhances immunogenicity and cross-protective efficacy against heterologous Salmonella challenge, Vaccine, 2016 .

7.       Xinxin Zhao, Qing Liu, Kangpeng Xiao, Qingke Kong. Identification of the crp gene in avain Pasteurella multocida and evaluation of the effects of crp deletion on its phenotype, virulence and immunogenicity, BMC Microbiol, 2016, 16(1):125.

8.       Xueyan Liu, Qing Liu*（共同第一作者）, Kangpeng Xiao, Qingke Kong. Attenuated Salmonella Typhimurium delivery of a novel DNA vaccine induces immune responses and provides protection against duck enteritis virus, Vet Microbiol, 2016, 186:189-98.

9.       Qiong Liu, Qing Liu*（共同第一作者）, Xinxin Zhao, Qingke Kong. Immunogenicity and Cross-Protective Efficacy Induced by Outer Membrane Proteins from Salmonella Typhimurium Mutants with Truncated LPS in Mice, International Journal of Molecular Sciences, 2016, 17(3).

10.   Xueyan Liu, Qing Liu, Kangpeng Xiao, Qingke Kong. Attenuated Salmonella Typhimurium delivery of a novel DNA vaccine induces immune responses and provides protection against duck enteritis virus, Vet Microbiol, 2016, 186:189-98 (IF=2.564).

11.   Qiong Liu, Qing Liu, Xinxin Zhao, Qingke Kong. Immunogenicity and Cross-Protective Efficacy Induced by Outer Membrane Proteins from Salmonella Typhimurium Mutants with Truncated LPS in Mice, International Journal of Molecular Sciences, 2016, 17(3) (IF=3.257).

12.   Xinxin Zhao, Qing Liu, Jie Zhang, Qingke Kong. Identification of a gene in Riemerella anatipestifer CH-1 that contributes to resistance to polymyxin B and evaluation of its mutant as a live attenuated vaccine, Microb Pathog, 2016, 91: 99-106.

13.   Kangpeng Xiao, Qing Liu, Xueyan Liu, Qingke Kong. Identification of the avian Pasteurella multocida phoP gene and evaluation of the effects of phoP deletion on virulence and immunogenicity, International Journal of Molecular Sciences, 2015, 17(1).

14.   Qiong Liu, Yanyan Li, Xinxin Zhao, Qing Liu, Qingke Kong. Construction of Escherichia coli mutant with decreased endotoxic activity by modifying lipid A structure, Mar Drugs,

2015, 13 (6): 3388-406.

15.   Xia Yu, Renyong Jia, Juan Huang, Bin Shu, Dekang Zhu, Qing Liu, Anchun Cheng. 2012. Attenuated Salmonella Typhimurium delivering DNA vaccine encoding duck enteritis virus UL24 induced systemic and mucosal immune responses and conferred good protection against challenge. Veterinary Research. 43(1): 56

16.   Q. Kong, David A. Six, Qing Liu, Christian R. H. Raetz, and Roy Curtiss III. 2012. Phosphate group of lipid A is essential for Salmonella enterica serovar Typhimurium virulence, and affects innate and adaptive immunity. Infection and Immunity. 80(9):3215-24.

17. 孔庆科，刘青. 应用遗传改造的鼠伤寒沙门氏菌治疗癌症的研究进展. 药品评价（肿瘤版），2012，正在出版.

18.   Kong, Q., David A. Six, Qing Liu, Christian R. H. Raetz, and Roy Curtiss III. 2011. Palmitoylation state impacts the innate and acquired immunity in Salmonella enterica serovar Typhimurium msbB mutant, Infection and immunity. 79(12):5027-38.

19.   Kong, Q., Jiseon Yang, Qing Liu, Praveen Alamuri, and Roy Curtiss III. 2011. Effect of deletion of genes involved in lipopolysaccharide core and O-antigen synthesis on virulence and immunogenicity of Salmonella enterica serovar Typhimurium. Infection and immunity. 79(10):4227-39.

20.   Kong, Q., David A. Six, Kenneth L. Roland, Qing Liu, Lillian Gu, C. Michael Reynolds, Xiaoyuan Wang, Christian R. H. Raetz, and Roy Curtiss III.. 2011. Salmonella synthesizing 1-monophosphorylated LPS exhibits low endotoxic activity while retaining its immunogenicity. Journal of immunology, 187(1): 412-23.

21.   Kong, Q., Qing Liu, Angela M Jansen, and R. Curtiss, III. 2010. Regulated delayed expression of rfc enhances the immunogenicity and protective efficacy of a heterologous antigen delivered by live attenuated Salmonella enterica vaccines. Vaccine, 28(37): 6094-103.

22.   Kong, Q., Qing Liu, K. L. Roland, and R. Curtiss, III. 2009. Regulated Delayed Expression of rfaH in an Attenuated Salmonella enterica Serovar Typhimurium Vaccine Enhances Immunogenicity of Outer Membrane Proteins and a Heterologous Antigen. Infect. Immun. 77:5572-5582.

23.   Qing Liu, Tianxiao Jiang, Dongguang Xiao, Jing Li. 2005. Construction of baker’s yeast with good leavening activity in lean, regular and sweet doughs.  Food and Fermentation Industry(食品与发酵工业), 3: 30-33

24.   Qing Liu, Dongguang Xiao, Jing Li. 2004. Optimization of sporulation and haploidization of S.Cerevisiae BY-6.  Science & Technology(科学与技术), 4:21-22

25.   Qing Liu, Dongguang Xiao, Jing Li. A simple determination method of Baker’s Yeast fermentation ability.  Science and Technology of food industry（食品工业科学与技术）, 2004,11:61-63

26.   Qing Liu, Dongguang Xiao, Tianxiao Jiang. A Simple Method Used for Observing Protoplasts under the Light Microscope.  Microbiology Science & Technology(微生物科学与技术), 2005,6

27.   Qing Liu, Dongguang Xiao, Tianxiao Jiang. Strains Selection of Baker’s yeast with Improved Freeze-tolerant Properties.  The science meeting of production and application of yeast. 2005, 7.

研究方向与兴趣:

1.  基于沙门氏菌为载体的疫苗构建，递送多糖，蛋白，病毒颗粒及其它活性小分子等。

2.  巴氏杆菌的致病机理。

欢迎有志于疫苗开发及微生物致病性研究的有志学生到本实验室工作；

联系邮件Email: qliu15(at)swu.edu.cn